品系描述：在25-90周龄之间的C57BL/6J的雄性和雌性小鼠。

应用领域：应用于免疫学、癌症、长寿基因和生物标记物等领域的研究。C57BL/6J 是使用最广泛的近交品系，也是第一个被全基因组测序的小鼠品系。C57BL/6J 小鼠对听源性惊厥具有抗性，骨密度相对较低，并会发展出年龄相关的听力丧失。它们也对饮食诱导的肥胖、II 型糖尿病和动脉粥样硬化易感。它们常被用于神经退行性疾病和骨密度相关的研究。

长期对C57BL/6J小鼠进行的研究揭示，老龄鼠易发多种病变，包括但不限于肾病、肾小球肾炎、嗜酸性巨噬细胞肺炎、脓肿、小鼠溃疡性皮炎、心肌病、脂肪肝以及淋巴结病变等。同时，老龄C57BL/6J小鼠还常出现生殖系统的萎缩现象，如睾丸萎缩、卵巢萎缩及卵巢囊肿，以及垂体囊肿、肾上腺色素沉积等内分泌系统异常。此外，淋巴瘤也是老龄C57BL/6J小鼠中较为常见的肿瘤类型。这些病变的发现和研究，为人体衰老及相关疾病的研究提供了宝贵的动物模型应用经验。

使用卡文斯C57BL/6J老龄鼠发表文献

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